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June 1974

Subcorneal Pustular Dermatosis Controlled by Vitamin E

Author Affiliations

Los Angeles

Arch Dermatol. 1974;109(6):914. doi:10.1001/archderm.1974.01630060082036

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To The Editor.—  Subcorneal pustular dermatosis (Snedden-Wilkinson disease) in two 3-year-old children was reported recently by Johnson and Cripps (Arch Dermatol 109:73, 1974). The authors pointed out the relatively unsatisfactory therapeutic response, both in their own patients and in the experience of others, to such medications as antibiotics, corticosteroids, and sulfones. In their concluding paragraph, they mentioned that, in an oral communication, we had stated that vitamin E was helpful.During the past eight or ten years, we have been conducting clinical investigations in the course of an office practice on the possible value of vitamin E in a number of recalcitrant dermatoses of obscure cause and have encountered some unexpected surprises. During this period, we have seen only one case of subcorneal pustular dermatosis, but the circumstances in this case and the therapeutic results were so dramatic that we thought a brief report was justified, so that this treatment

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