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July 1974

Bullous Pemphigoid and Dermatitis Herpetiformis: Histopathologic Differentiation of Bullous Pemphigoid and Dermatitis Herpetiformis

Author Affiliations


From the Section of Dermatology, Department of Medicine, the University of Chicago Pritzker School of Medicine, Chicago. Dr. Eng is now with the Loyola University Medical Center, Maywood, Ill. Dr. Moncada is now with the Escuela de Medicin Universidad auto'noma de San Luis, Potosi, Mexico.

Arch Dermatol. 1974;110(1):51-57. doi:10.1001/archderm.1974.01630070019003

This study deals with the histopathologic differentiation of dermatitis herpetiformis and bullous pemphigoid in 17 cases where the diagnoses were supported by immunofluorescent examinations. Two distinct patterns of inflammatory infiltration were observed in five cases of dermatitis herpetiformis, (1) papillary leukocytic infiltrates associated with leukocytoclasia and (2) perivascular mixed cellular infiltrates, with edema. In the 12 cases of bullous pemphigoid studied, two major histopathologic inflammatory patterns were also observed, (1) a dermal infiltrate-rich pattern and (2) a dermal infiltrate-poor pattern.

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