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July 1974

Treatment of Primary Biliary Cirrhosis

Author Affiliations

Los Angeles

Arch Dermatol. 1974;110(1):132. doi:10.1001/archderm.1974.01630070090036

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To the Editor.—  Two white married women were referred to me by their internists, for relief of their severe increasing generalized pruritus, yellow bronzing hyperpigmentation, spotty melanosis, and insomnia. Blood studies revealed a large increase in serum glutamic oxaloacetic transaminase. Diagnosis in both cases was primary biliary cirrhosis.Patient 1, age 56, suffered another complication of a mild adult-type diabetes mellitus that was under good control; she had complained of jaundice for 9½ years.Patient 2 had noted jaundice for a period of three years, since age 43.The successful treatment of neonatal jaundice by the use of fluorescent lights reported in recent literature suggested to me the idea of using the total body exposure cabinet for irradiation of the entire body evenly. Irradiation was initially given for nine minutes and increased weekly to the present duration of 12.Dramatic relief of pruritus, insomnia, and decreasing pigmentation was obtained in

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