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July 1974


Arch Dermatol. 1974;110(1):137-138. doi:10.1001/archderm.1974.01630070091039

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Sclerosing Lipogranuloma. Presented by Brian Potter, MD, Alvin L. Francik, MD.  A 42-year-old white woman noticed a painless swelling of her right upper eyelid. On examination, there was a yellow discoloration across the eyelid extending from the inner canthus, causing the eyelid to protrude. At surgery, a "xanthoma" was found involving the skin and subcutaneous tissue. Fat, which had herniated through the orbicularis muscle, was removed. Histopathologic examination showed that the corium was infiltrated by foamy cells with indistinct cytoplasm and small basophilic nuclei arranged in bands parallel to the epidermis. Part of the excised muscle and subcutaneous fat was infiltrated by large foamy cells. Both muscle and fat tissue exhibited chronic inflammatory changes and focal degeneration, being infiltrated by lymphocytes clustered about blood vessels and in small nodules. Eosinophils and Touton giant cells were present.Two years later, there was a gradual recurrence of the mass

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