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July 1974

Immediate Hypersensitivity: The Molecular Basis of the Allergic Response

Author Affiliations

Rochester, Minn

Arch Dermatol. 1974;110(1):146. doi:10.1001/archderm.1974.01630070098044

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In recent years, knowledge of the mechanisms of immediate hypersensitivity has increased rapidly. Dr. Stanworth's monograph is part of the series entitled Frontiers in Biology, and he presents a detailed account of the background studies and the new findings that have contributed to our current concepts of immediate hypersensitivity.

The book deals with measurements of immediate hypersensitivity reactions, allergen structure and function, isolation and characterization of reagins, structural basis of reagin activity, immediate hypersensitivity in experimental animals, cellular aspects of reagin formation and disappearance, mechanism of release of mediators of immediate hypersensitivity, and inhibition of immediate hypersensitivity responses. The author's references include some articles published in 1972. His writing is lively and clear, and he reports on observations made in his own laboratory.

The clinical diagnosis and management of the immediate hypersensitivity diseases are not discussed, but some speculations are included about future approaches to treatment that would be made

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