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September 1974

T and B Lymphocytes in Atopic Eczema

Author Affiliations

From the departments of dermatology (Drs. Luckasen and Goltz), laboratory medicine and pathology (Dr. Kersey and Mr. Sabad), University of Minnesota, Minneapolis.

Arch Dermatol. 1974;110(3):375-377. doi:10.1001/archderm.1974.01630090013002

Using E and EAC rossette assays, T and B lymphocytes were quantitated in patients with atopic eczema. Adult patients had percentages of T lymphocytes at the lower end of the range of normal. When evaluated as a group, their mean percentage was significantly lower than that of controls. B lymphocytes were present in normal percentages. Absolute numbers of both T and B lymphocytes were significantly decreased. These data suggest that there is a defect in cell-mediated immunity in the atopic population that may be important in the pathogenesis of the disease.

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