A 3-year-old boy had three episodes of erythema nodosum-like lesions that were initially thought to be associated with a granulomatous process. They were later found to be due to acute granulocytic leukemia, with histologic evidence of leukemic cells in the cutaneous lesions.
Ciro Valent Sumaya, Sylvia Babu, Richard J. Reed. Erythema Nodosum-like Lesions of Leukemia. Arch Dermatol. 1974;110(3):415–418. doi:10.1001/archderm.1974.01630090053010