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November 1974

Kyrle Disease: Treatment With Topically Applied Tretinoin

Author Affiliations

From the Department of Dermatology, University of Pennsylvania School of Medicine, Philadelphia and the Dermatology Section, Veterans Administration Hospital, Philadelphia.

Arch Dermatol. 1974;110(5):762-765. doi:10.1001/archderm.1974.01630110056015

Successful treatment of Kyrle disease was achieved with topically applied tretinoin. Its effectiveness appears to depend on its ability to increase epidermal proliferation and to impair keratinization. Because of the beneficial results achieved, a hypothesis that keratinization is excessive in comparison with epidermal proliferation may be valid in the pathogenesis of this disorder.

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