Toxic epidermal necrolysis (TEN) appears to be a syndrome occurring as the end result of a number of different causes, including treatment with certain drugs, certain systemic diseases, and infections caused by particular strains of staphylococci. Toxic epidermal necrolysis has been reported to occur secondary to administration of a number of vaccines and to immunizations; however, to our knowledge, it has not been previously described as occurring secondary to measles vaccination.