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November 1974

Treatment Schedule for Secondary Syphilis

Arch Dermatol. 1974;110(5):810. doi:10.1001/archderm.1974.01630110088032

To the Editor.—  In a recent article titled "Dose-Related Seroreversal in Syphilis," Durst et al1 present data that appear to suggest a new treatment schedule for secondary syphilis. We should like to point out several areas in which their data do not support this recommendation and may be misleading.The underlying assumption of the report is that VDRL test seroreversal in secondary syphilis, in many cases, takes longer than 24 months, when the standard therapeutic regimen of 2,400,000 units of penicillin G benzathine is used. The two sources for this assumption, cited by the authors, are Schroeter et al2 and Capinski et al.3 Schroeter's sample of 93 patients with secondary syphilis was treated with one of five different therapeutic regimens, and from the published material, one cannot discern the seroreversal rate among the group treated with penicillin G benzathine.Capinski et al3 utilized doses of penicillin

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