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November 1974

Treatment Schedule for Secondary Syphilis-Reply

Arch Dermatol. 1974;110(5):810-811. doi:10.1001/archderm.1974.01630110088033

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To the Editor.—  The query of Drs. Kaufman and Kraus was read with interest and our reply is as follows.We agree that from reading Arnold Schroeter's publication (JAMA 221:471, 1972) it is difficult to isolate those patients treated with penicillin G benzathine and to follow up their respective serologic titers over a period of two years. However, personal communication with Dr. Schroeter reaffirmed an underlying feeling of his paper, ie, that a certain percentage of individuals treated with "conventional" doses of penicillin G benzathine remain seropositive at the end of 24 months. Whether this percentage is 5% or 25% is irrelevant at this time, if it is true that larger doses of this drug could serorevert 99% or 100% of the patients.We also agree with the good doctors that, in general, serologic tests in secondary syphilis become nonreactive 12 to 18 months after treatment, but we would urge

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