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December 1974

Topical Photosensitizers: Influence of Vehicles on Penetration

Author Affiliations

From the Department of Dermatology, University of Pennsylvania, School of Medicine, Philadelphia.

Arch Dermatol. 1974;110(6):868-870. doi:10.1001/archderm.1974.01630120018004

The photosensitizing capacity of crude coal tar, methoxsalen, and chlorpromazine was found to be strongly influenced by the choice of vehicle. When coal tar was incorporated in an optimal base, occlusion had little influence on its phototoxicity. Although no single base was found to provide optimal absorption for these compounds, emulsion-type creams were generally superior to petrolatum. Polyethylene glycol was a uniformly poor vehicle and tended to neutralize the activity of all these substances.

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