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December 1974

Tinea Versicolor Treatment

Author Affiliations

Duluth, Minn

Arch Dermatol. 1974;110(6):956. doi:10.1001/archderm.1974.01630120088025

To the Editor.—  Although tinea versicolor can be successfully treated with several preparations, some agents have shortcomings, which warranted trial of another preparation.Sodium thiosulfate is slow acting and often ineffective. Tolnaftate requires prolonged use for widespread lesions.1 Selenium sulfide (2.5%) shampoo is usually effective,2-4 but there is concern for toxicity with prolonged treatment, or treatment of large areas.5Sulfur and salicylic acid have been used as fungicides, and occasionally for treatment of tinea versicolor. An easily available, safe, and cosmetically pleasant formulation was chosen, which contained 2% micropulverized sulfur and 2% salicylic acid in a shampoo base (Sebulex). Half of the patients were treated with an oil-in-water lotion (Keri Lotion) as a placebo.Thirty-nine volunteers had typical spores and hyphal segments on potassium hydroxide cellophane tape preparations of skin lesions.6 A third party randomized the subjects, using a table of random numbers, and handed out