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December 1974


Arch Dermatol. 1974;110(6):963-964. doi:10.1001/archderm.1974.01630120091031

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Erythema Dyschromicum Perstans (Ashy Dermatosis). Presented by Gerald A. Gellin, MD, Regina Hilger, MD.  A 20-year-old man from El Salvador is one of the original patients described by Dr. C. O. Ramirez. Asymptomatic, grayishbrown patches have progressively involved the patient's face, trunk, and extremities for more than ten years. There is no antecedent erythema and no history of drug ingestion. The patient's general health remains good. No other family member is similarly affected.Results of a complete blood cell count, liver function tests, liver scan, and the ceruloplasmin value were normal. Serologic tests for syphilis, lupus erythematosus and hepatitis-associated antigen tests were negative.A skin biopsy specimen from a hyperpigmented area was studied.


Dr. D. R. Harris:  Histologic examination of the skin biopsy specimen shows incontinence of pigment. The basal cell layer is intact, and the epidermis is mildly irregular. The main pathologic change is in the superficial dermis,

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