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January 1975

Anti-Single Stranded DNA Antibodies in Scleroderma

Arch Dermatol. 1975;111(1):129. doi:10.1001/archderm.1975.01630130131021

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To the Editor.—  In the November 1972 issue of the Archives, in their article on anti-native DNA antibodies in discoid lupus erythematosus (LE), Mandel et al reported for the first time that, in diseases other than systemic LE, serum DNA binding activity may be elevated. This was in contrast to former publications that emphasized the excellent specificity of this test for systemic LE.With the use of iodine 125-labeled single-stranded calf thymus DNA in the ammonium precipitation technique of Farr, we have detected elevated anti-DNA serum antibodies of individuals suffering from systemic scleroderma. The determinations were accomplished with high or low radioactively labeled DNA alternatively. In both assays, the difference between affected individuals and healthy controls was marked. By means of high radioactively labeled DNA, 23 of 31 patients with scleroderma had values above the 99% security limit of the controls; with low labeled DNA, 12 of 49 had these

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