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February 1975

Antinuclear Antibodies: II. The Prognostic Significance of Nuclear Immunofluorescent Patterns in Lupus Erythematosus

Author Affiliations

From the Department of Dermatology, Henry Ford Hospital, Detroit.

Arch Dermatol. 1975;111(2):203-207. doi:10.1001/archderm.1975.01630140061006

Nuclear immunofluorescent patterns in lupus erythematosus (LE) were correlated with the clinical picture. Patterns were classified into three groups of prognostic significance: (1) Poor—Shrunken peripheral fluorescence was found in patients with severe systemic lupus erythematosus (SLE), 60% demonstrating renal involvement. (2) Intermediate—This included the peripheral and thready patterns, associated with 33% renal involvement in patients with SLE. (3) Good—Large and small speckle-like threads were seen in cases of very benign LE.

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