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July 1975

Minocycline in Staphylococcal Soft-Tissue Infections

Author Affiliations

From the Section of Infectious Diseases, Department of Medicine, and the Department of Surgery, University of Louisville School of Medicine, Louisville.

Arch Dermatol. 1975;111(7):874-876. doi:10.1001/archderm.1975.01630190064005

Fifteen patients who had severe Staphylococcus aureus infections were treated with minocycline for 6 to 24 days; all responded satisfactorily. Where possible, posttherapy cultures were taken, and in all instances, the pathogen was eradicated. There were no adverse reactions.

Minocycline proved to be an acceptable and an effective alternative for staphylococcal soft-tissue infections. It has the following advantages: (1) it is administered orally on a twice-daily dosage schedule, which facilitates patient compliance; (2) its toxicity is well defined and is not troublesome during short-term therapy; and (3) it penetrates tissues in therapeutic amounts and yields serum levels that are well above the minimum inhibitory concentrations of most staphylococci.

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