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July 1975

Autoantibodies in Alopecia Areata

Author Affiliations

Padua, Italy

Arch Dermatol. 1975;111(7):927-928. doi:10.1001/archderm.1975.01630190117023

To the Editor.—  Many authors have reported the association of alopecia areata (AA) with one or more autoimmune diseases, such as Addison disease,1-3 pernicious anemia,2,3,5,8 idiopathic hypoparathyroidism,1-5 premature ovarian failure,3,5 ulcerative colitis,6,7 hypothyroidism,3,8 some cases of diabetes mellitus,8 and moniliasis.1-5No notable incidence of thyroid antibodies was found by Cunliffe et al9 in 71 patients with isolated AA. On the contrary, Kern et al10 reported a high incidence of thyroid, adrenal, and parietal cell antibodies.We performed an immunological study of 52 patients with isolated AA to clarify the possible relationship between AA and autoimmunity.

Subjects and Methods.—  Fifty patients with typical cases of AA and two with alopecia totalis were examined. None of them had previously received corticosteroid therapy. Of the 52 patients, who ranged from 3 to 63 years in age, 33 were men and 19 were women.

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