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July 1975

Multiple Flat Warts Due to Tetracycline

Author Affiliations

Palo Alto, Calif

Arch Dermatol. 1975;111(7):930. doi:10.1001/archderm.1975.01630190120029

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To the Editor.—  A patient with multiple flat warts is often a frustrating clinical problem to the practicing dermatologist. Many methods of treatment have been used over the years, but there is no single one which is predictably effective in all cases.I have recently seen two patients, both young women, in whom multiple flat warts of the face disappeared within two weeks of stopping treatment with orally administered tetracycline, a drug which had been prescribed for coexisting acne.In the first patient, after several months of tetracycline therapy, the warts appeared and persisted despite local treatment with liquid nitrogen, peeling lotions, and tretinoin. Eventually the acne improved and tetracycline was discontinued. The warts disappeared completely within two weeks.In the second patient, tetracycline had been prescribed only a month before the flat warts on the face were noted. Because they did not respond to a light application of liquid

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