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August 1975

Clindamycin vs Placebo as Adjunctive Therapy in Moderately Severe Acne

Author Affiliations

From the departments of internal medicine (Drs. Christian and Krueger) and dermatology (Dr. Krueger), University of Utah College of Medicine, Salt Lake City.

Arch Dermatol. 1975;111(8):997-1000. doi:10.1001/archderm.1975.01630200057005

Eighty-three patients with moderately severe acne were entered into a doubleblind study utilizing clindamycin and placebo. Counts of comedones and pustules were made at intervals during a 13-week period. Clindamycin resulted in noticeable improvement of acne in 85% of subjects while in the placebo group improvement was present in 38%. There was also an unexplained reduction of total comedone count in the clindamycin-treated group. Severe side effects occurred in two of 44 patients receiving clindamycin (diarrhea, 1 and rash, 1); although an additional eight patients receiving clindamycin experienced mild diarrhea, discontinuation of therapy was not required. Clindamycin appears to be a valuable additional drug in the treatment of acne.

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