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September 1975

Immunocytochemical Localization of Cathepsin D in Rabbit Skin

Author Affiliations

From the Strangeways Research Laboratory, Cambridge, England, and the Division of Dermatology, Department of Medicine, Montefiore Medical Center, New York, and the Department of Medicine, Albert Einstein College of Medicine, New York. Dr. Poole, Immunology Division Dept of Pathology, University of Cambridge, England.

Arch Dermatol. 1975;111(9):1150-1153. doi:10.1001/archderm.1975.01630210066006

The lysosomal proteinase cathepsin D has been localized in rabbit skin by immunocytochemical techniques. The enzyme was found in the basal layer of the epidermis, hair follicles, sebaceous glands, fibroblasts, and endothelial cells. An autoradiographic technique, using the Fab' fragment of IgG, was also used for more effective identification of cell types that contain cathepsin D.

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