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September 1975

Eczema Herpeticum: Treatment With Methylene Blue and Light

Author Affiliations

From the Infectious Disease Service, New England Medical Center Hospital, and the Department of Medicine, Tufts University School of Medicine (Dr. Chang), and Peter Bent Brigham Hospital and Department of Medicine, Harvard Medical School (Dr. Weinstein), Boston.

Arch Dermatol. 1975;111(9):1174-1175. doi:10.1001/archderm.1975.01630210090012

Kaposi varicelliform eruption due to herpes simplex virus (eczema herpeticum) is a serious disease in infants, with occasional fatal outcome. Photoinactivation therapy consisting of local application of methylene blue followed by light exposure resulted in rapid improvement both clinically and virologically. Methylene blue, at a concentration of 105M was found to be viricidal to herpesvirus in the light but not in the dark.