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To the Editor.—
A snap judgment deserves a snappy answer. O'Connell and Karassik are science fanatics and cannot imagine studies in which controls are superfluous. The orthodox always hold that the rules permit no exceptions—out, Heretic!It comes down to knowing the model with which one is working. Recalcitrant, steroid-resistant, longstable, unchanging psoriatic plaques do not undergo complete clearing by placebo ointments, weather changes, a boom in the stock market, a new mistress, exposure to faith healers, or even delirious dermatologists. They don't go away spontaneously within a few weeks, except when driven away by potent medications. I conclude that O'Connell and Karassik believe in magic, Philadelphia magic at that (the worst kind).We recently published photos of squares of ivory-white skin produced in deeply pigmented blacks by topical application of a new depigmentation formula. One of the reviewers offered the criticism that there were no controls and hence recommended
Kligman AM. Topical Colchicine Therapy-Reply. Arch Dermatol. 1975;111(9):1213. doi:10.1001/archderm.1975.01630210129019
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