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Few problems frustrate the clinician more than the patient who develops a drug eruption while taking multiple medications. A decision to stop all medication may lead to clearing of the skin lesions but may create unhappy consequences for the noncutaneous problems of the patient.
Bruinsma's manual is organized with chapters listing drugs that produce acne, alopecia, pigmentary lesions, exanthemas, exfoliative erythroderma, urticaria, eczema, photosensitivity, lupus erythematosus, vascular lesions, purpura, porphyria, lichenoid lesions, fixed eruptions, vesiculo-bullous lesions, erythema multiforme bullosa, toxic epidermal necrolysis, and pruritus. Separately, drugs are listed with the type of associated skin changes and a 1 to 4 point ranking system in regard to the relative frequency of each type of response. Adverse reactions are tabulated with the drug(s) producing them, and references are made to the text or to one or more of 190 pertinent articles. There are also references to 17 review articles.
A Guide to
Smith JG. A Guide to Drug Eruptions. Arch Dermatol. 1975;111(9):1223. doi:10.1001/archderm.1975.01630210139031
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