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October 1975

Topically Applied Griseofulvin in Prevention and Treatment of Trichophyton mentagrophytes

Author Affiliations

From the departments of dermatology (Dr. Epstein) and pharmacy (Drs. Shah and Riegelman), University of California, San Francisco, and the Letterman Army Institute of Research, Presidio of San Francisco (Dr. Jones). Dr. Jones is currently with the Department of Dermatology, University of Michigan, Ann Arbor, Mich.

Arch Dermatol. 1975;111(10):1293-1297. doi:10.1001/archderm.1975.01630220057002

• Griseofulvin is not considered effective in treatment of superficial fungal infections. However, when applied topically in organic solvents, the drug appeared in very high concentration in all levels of stratum corneum, and it generally persisted there in measurable amounts for four or more days after a single application. Based on this observation, doubleblind experimental prophylactic and therapeutic studies were conducted. Topically applied griseofulvin in alcohol solution was highly effective in preventing experimentally induced Trichophyton mentagraphytes infection, but it had no therapeutic effect once the infection was initiated. Topically administered griseofulvin may prove useful in prevention of recurrences or as an adjunct to therapy in selected cases of superficial fungal infection.

(Arch Dermatol 111:1293-1297, 1975)

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