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October 1975

Diagnosis of Systemic Lupus Erythematosus: Importance of Antinuclear Antibody Titers and Peripheral Staining Patterns

Author Affiliations

From the State University of New York at Buffalo (Drs. Nisengard and Beutner and Ms. Jarrett), and Warsaw Medical School, Poland (Drs. Jablonska, Chorzelski, and Blaszcyk).

Arch Dermatol. 1975;111(10):1298-1300. doi:10.1001/archderm.1975.01630220062003

• Titers and patterns of antinuclear antibodies (ANA) in sera from 134 normal blood donors, 20 patients with rheumatoid arthritis, 15 patients with systemic scleroderma, and 32 patients with diagnosed or suspected systemic lupus erythematosus (SLE) were studied. The difference between the findings with sera of patients with SLE and normal subjects in terms of high ( ≥ 160) titers of ANA was greater than in terms of peripheral staining patterns. However, in comparing sera from patients with SLE with sera from patients with other connective tissue diseases, greater differences were found in the incidence of peripheral patterns of ANA compared to differences in the frequency of high ANA titers. Maximum specificity in the diagnosis of SLE was achieved when both titers and patterns of ANA were considered.

(Arch Dermatol 111:1298-1300, 1975)

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