• Acquired ichthyosis was recognized in four patients, in whom the associated malignant disorders were carcinoma of the lung, breast, and cervix. This skin lesion may be a valuable clinical sign in recognizing the existence of a malignant condition. Although the emergence of an ichthyosiform dermatosis may have serious prognostic implications, it may also be useful in monitoring the course of the malignant disorder and the patient's response to therapy. The relationship to nonlymphoproliferative malignant neoplasms may be more common than has been previously recognized.
(Arch Dermatol 111:1446-1447, 1975)
Flint GL, Flam M, Soter NA. Acquired IchthyosisA Sign of Nonlymphoproliferative Malignant Disorders. Arch Dermatol. 1975;111(11):1446–1447. doi:10.1001/archderm.1975.01630230048008
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