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November 1975

Chlorpromazine Photoallergy: Coexistence of Immediate and Delayed Type

Arch Dermatol. 1975;111(11):1469-1471. doi:10.1001/archderm.1975.01630230071013

• A 54-year-old woman had a recurrent pruritic eruption in light-exposed areas. She had a combination of three types of hypersensitivity to chlorpromazine, ie, allergic contact dermatitis, photocontact dermatitis, and immediate allergic photosensitivity. Immediate wheal reactions were found after long-wave ultraviolet light irradiation at photopatch test and intradermal injection sites with chlorpromazine. These responses were differentiated from phototoxic reactions. A positive passive transfer reaction was also observed. To my knowledge, chlorpromazine photosensitivity of the immediate type has not been previously described.

(Arch Dermatol 111:1469-1471, 1975)