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November 1975

Cromolyn Therapy in Chronic Infantile Eczema

Author Affiliations

Los Alamos, NM

Arch Dermatol. 1975;111(11):1537. doi:10.1001/archderm.1975.01630230135031

To the Editor.—  The principal effect of cromolyn sodium (disodium cromoglycate) is believed to be inhibition of the release of chemical mediators on anaphylaxis from sensitized mast cells.1 There are some indications2,3 that cromolyn taken orally may inhibit the development of gastrointestinal manifestations of food allergy. Also, cromolyn may block the development of remote manifestations, such as urticaria, following ingestion of an offending food allergen.This report documents what is believed to be the first recorded use of cromolyn in the treatment of infantile eczema.

Report of a Case.—  The patient is a 6-year-old boy, whose eczema was first diagnosed at eight weeks of age. His disease was of sufficient intensity to require hospitalization on five occasions during the first 24 months of life. Intermittent therapy with oral steroids as well as nearly continuous application of topical steroids have been necessary to control his skin lesions.At five

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