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January 1976

Malignant Hepatoma Associated With Acquired Hepatic Cutaneous Porphyria

Author Affiliations

From the Department of Dermatology, Hull Royal Infirmary, Hull, England.

Arch Dermatol. 1976;112(1):78-82. doi:10.1001/archderm.1976.01630250042014

• A 60-year-old woman with a threeyear history of an acquired hepatic cutaneous porphyria was discovered to have a porphyrin-producing malignant hepatoma. An attempt was made to treat her with fluorouracil perfused through a hepatic artery catheter. It did not produce shrinkage of the tumor, but the patient remains alive and ambulant a year after the infusion, although her skin lesions (scarring, bulla formation, and hyperpigmentation) on the fingers, back of hands, and face persist and she continues to excrete abnormally high quantities of porphyrin in her feces.

(Arch Dermatol 112:78-82, 1976)