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January 1976

Threads and Fine Threads

Arch Dermatol. 1976;112(1):122. doi:10.1001/archderm.1976.01630250066025

In Reply.—  The key to the questions asked by Dr Pedro is that he has misquoted and consequently misinterpreted our statements concerning the relationship between threads and fine threads1-3 and the two separate antibodies to extractable nuclear antigen (ENA) of Sharp et al.4 A serum exchange with Gordon C. Sharp, MD, showed that the pattern he reported as speckles4 (also referred to as such in the cooperative study on immunofluorescence tests5) could in fact be separated morphologically into two patterns, threads and fine threads.1 We suggested that these two patterns might represent the two antibodies reported to be reactive with ENA.1 Specifically, we suggested that the fine threads might possibly represent the antibody to ribonucleasesensitive ENA, seen in patients with mixed connective tissue (MCT) disease,4 while the threads may be produced by the antibody to ribonuclease-resistant ENA,6 found in patients with systemic lupus erythematosus

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