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February 1976

Topically Applied Antibiotics in Acne Vulgaris: Clinical Response and Suppression of Corynebacterium acnes in Open Comedones

Author Affiliations

From the Division of Dermatology, University of California School of Medicine, San Diego (Dr Resh), and the Division of Dermatology, Scripps Clinic and Research Foundation, La Jolla, Calif (Dr Stoughton).

Arch Dermatol. 1976;112(2):182-184. doi:10.1001/archderm.1976.01630260010003

• Topical antibiotics were used on patients with acne vulgaris. Corynebacterium acnes organisms from open comedones were quantitated during treatment, and the progress of the disease was evaluated. Clindamycin lotion completely suppressed the growth of C acnes organisms, whereas erythromycin and tetracycline did not depress the C acnes counts. Taken as a group, these antibiotics gave a substantial improvement of the disease on the treated side as compared with paired untreated sides of the face and back.

(Arch Dermatol 112:182-184, 1976)

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