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February 1976

Erythema Multiforme and Hematuria

Author Affiliations

Burlington, Vt

Arch Dermatol. 1976;112(2):261-262. doi:10.1001/archderm.1976.01630260061017

To the Editor.—  Recently, a 66-year-old man noted the onset of gross hematuria during an acute episode of erythema multiforme. Characteristic vesicobullous lesions were present on all body surfaces, including the glans penis near the urethral meatus. Urine culture grew Escherichia coli.Infection and malignancy are among the mechanisms thought to trigger erythema multiforme.1,2 Both conditions not only may stimulate an acute attack but also may produce hematuria. In addition, erythema multiforme per se may result in hematuria via involvement of the bladder, urethra, or kidneys.1,3,4Urologic consultation was obtained in this case. Intravenous pyelography showed a filling defect on the left wall of the bladder. A 2-cm grade 2, stage A, transitional-cell bladder cancer was cystoscopically resected. No vesicobullous lesions were seen in the lower part of the urinary tract.Our purpose in this communication is to emphasize that a urologic workup is imperative for patients with