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February 1976

Vitamin A in Darier Disease

Arch Dermatol. 1976;112(2):262. doi:10.1001/archderm.1976.01630260062019

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To the Editor.—  Harold C Fishman, MD, reported a case of acute, eruptive Darier disease in an adult (111:221-222, 1975).On Dec 4,1974, a fair-complexioned white man, age 57, was seen with a similar eruption of acute onset. He had received no previous treatment and was undiagnosed.He failed to respond to triamcinolone acetonide lotion or fluocinolone acetonide (Fluonid) solution. On Jan 16, 1975, he was given 15 mg/day of prednisolone, and tetracycline hydrochloride, 750 mg/day, for one week in addition to local steroid drugs without any change in his condition. Paul Hirsch, MD, confirmed the biopsy diagnosis as Darier disease.On Jan 31, 1975, all steroids were discontinued and the patient was given 100,000 units of vitamin A (Aquasol A) intramuscularly, and started therapy with 500,000 units of orally administered vitamin A. In one week, the pruritus had ceased and all lesions were regressing.On Feb 15, 1975, the

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