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March 1976

ClofazimineA New Agent for the Treatment of Pyoderma Gangrenosum

Author Affiliations

From the departments of dermatology, Uppsala University Hospital, Uppsala (Drs Michaëlsson, Öhman, and Trolin), Linköping University Hospital, Linköping (Drs Molin and Skogh), Sundsvall Hospital, Sundsvall (Dr Gip), and Falun Hospital, Falun (Dr Lindström), Sweden.

Arch Dermatol. 1976;112(3):344-349. doi:10.1001/archderm.1976.01630270024006

• Eight patients had pyoderma gangrenosum. They were given a phendimetrazine tartrate derivative, clofazimine (Lamprene [Britain]), which is a chemotherapeutic agent used mainly in certain mycobacterial infections and which also has phagocytosis-enhancing properties. The effect of this drug was remarkably good, with rapid healing of the lesions commencing 3 to 14 days after treatment was started. The mechanism for the effect of clofazimine in pyoderma gangrenosum is not known.

(Arch Dermatol 112:344-349, 1976)