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April 1976

Gluconate Zinc in Acrodermatitis Enteropathica

Author Affiliations

From the Division of Dermatology, University Hospitals of Cleveland (Drs Hirsh and Michel), and the Department of Surgery, Cleveland Metropolitan General Hospital (Dr Strain), Case Western Reserve University School of Medicine, Cleveland.

Arch Dermatol. 1976;112(4):475-478. doi:10.1001/archderm.1976.01630280005001

• Two children with characteristic findings of acrodermatitis enteropathica were found to have low serum zinc levels prior to therapy. Treatment with zinc gluconate in low dosages resulted in an increase in serum zinc levels and clinical improvement. All family members studied had low serum zinc levels. In addition, we noted a change of hair color to red and excessive drooling just prior to exacerbations in these two patients. The hair color returned to normal with remission.

(Arch Dermatol 112:475-478,1976)