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April 1976

Iodide-Induced Immunofluorescence in Dermatitis Herpetiformis

Author Affiliations

Lackland Air Force Base, Tex

Arch Dermatol. 1976;112(4):555. doi:10.1001/archderm.1976.01630280073025

To the Editor.—  Dermatitis herpetiformis (DH) is an uncommon but curious dermatologic disease. Factors suggesting an immunologic basis for this disease include the presence of gastric and thyroid autoantibodies,1 an increased incidence of antireticulum antibodies,2 and the characteristic finding of deposits of IgA at the dermal papillae or in a linear deposition at the dermoepidermal junction.Another unique characteristic is the noticeable sensitivity of DH to iodides. Epidermal patch testing with 20% potassium iodide has been reported to evoke a flare of the disease.3 Jablonska and Chorzelski have reported that "the findings of immunofluorescence are as a rule positive in the lesions provoked by iodine given systemically."4 The reason for iodide sensitivity and its induction of positive immunofluorescence remains unclear and is difficult to correlate with the evidence linking this disease with celiac disease and gluten sensitivity.The purpose of this report is to describe a

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