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Colchicine is a potent agent. So are x-rays, corticosteroids, and immunosuppressives. We use all of these—with caution.Recalcitrant psoriasis is a dreadful affliction. No treatment is completely safe. We shall continue to take risks in treating ruinous diseases of the skin unless experience, not theoretical objections, shows that the hazards outweigh the benefits.Gaylarde and Sarkany probably would have written a letter to the editor when Goeckerman proposed his famous treatment that employed not only a known carcinogen but carcinogenic radiation as well. Our British friends need to be reminded of John Hunter's maxim, "Don't think, try."