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April 1976

IgM Deposits in Tuberculoid Leprosy

Author Affiliations

Lackland Air Force Base, Tex

Arch Dermatol. 1976;112(4):557-558. doi:10.1001/archderm.1976.01630280075032

To the Editor.—  Deposition of IgM has recently been demonstrated at the dermoepidermal junction in lesions of lepromatous leprosy by means of immunofluorescence microscopy.1,2 We wish to report what we believe to be the first demonstration of IgM in a lesion of tuberculoid leprosy.

Report of a Case.—  A 42-year-old man had two gradually enlarging, annular, slightly scaly plaques with hyperpigmented borders on his left thigh and right ankle of six months' duration. These lesions were devoid of hair and anesthetic to soft touch, pain, heat, and cold. A biopsy specimen, on routine staining with hematoxylin-eosin, showed a granulomatous infiltrate composed of epithelioid cells with a few giant cells and many lymphocytes. In some areas the infiltrate invaded the epidermis, and invasion of nerves was seen in the dermis. An acid-fast stain demonstrated no bacilli.Involved skin was also examined with the use of direct immunofluorescence microscopy, and

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