To the Editor.—
We have recently noted large, apparently random, day-to-day fluctuations in the relative number of circulatory Sézary cells in the peripheral blood of patients with Sézary syndrome. The Figure depicts such a situation in a 70-year-old man with a three-year history of documented Sézary syndrome. The flucPrednisone, 30mg 25mg 20mg 12 10 2 28 30 31 3 4 6 7 8 9 10 11 12 13 14 Jan Feb Daily count of Sézary cells in peripheral blood. tuating Sézarycytosis was observed during a period when the patient was hospitalized for exacerbation of his erythroderma. For several months prior to this hospitalization, the patient had been receiving a single daily oral dose of 30 mg of prednisone and a dose of 2 mg of chlorambucil (Leukeran) twice daily. The dose of prednisone was decreased twice during the period in which serial Sézary cell counts were done. The patient
Heaphy MR, Winkelmann RK. Variations in Peripheral Sézary Cell Count. Arch Dermatol. 1976;112(4):560. doi:10.1001/archderm.1976.01630280078038
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