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May 1976

Leser-Trélat Sign With Porphyria Cutanea Tarda and Malignant Hepatoma

Author Affiliations

Sheffield, England

Arch Dermatol. 1976;112(5):730. doi:10.1001/archderm.1976.01630290072020

To the Editor.—  In the June 1975 issue of the Archives, Gitlin and Pirozzi1 expressed a desire to stimulate comments regarding the Leser-Trélat sign. This prompts me to report a case in which the presence of eruptive seborrheic keratoses led to the search for an internal malignant neoplasm.

Report of a Case.—  A 72-year-old man was seen in June 1975; at the time, he had an 11-month history of blisters on the scalp and hands after minor trauma and a six-week history of "itchy warts" on the back and chest. In February 1974, an inguinal hernia on his left side was repaired; hepatomegaly was noted at that time.Physical examination in June 1975 showed eruptive seborrheic keratoses on the chest and back, milia on the dorsa of both hands, and bullae on the hands and forehead. The liver was enlarged 4 cm below the costal margin. A clinical diagnosis