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June 1976

Immunologic Responses in Patients With Lepromatous Leprosy

Author Affiliations

From the sections of dermatology (Drs Rea and Levan) and clinical immunology and rheumatic diseases (Drs Quismorio, Harding, and Friou), Department of Internal Medicine, and the Section of Gynecologic Oncology (Dr Di Saia), Department of Obstetrics and Gynecology, University of Southern California School of Medicine, Los Angeles; and the departments of dermatology, internal medicine, and obstetrics and gynecology, Los Angeles County-University of Southern California Medical Center. Dr Harding is now at the Radcliffe Infirmary, Oxford, England. Dr Nies is now at Harbor General Hospital, Torrance, Calif.

Arch Dermatol. 1976;112(6):791-800. doi:10.1001/archderm.1976.01630300005001

• Immunologic responses were measured in 46 patients with lepromatous leprosy. These patients were not distinguishable from controls on the basis of responses to soluble intradermal antigens, sensitization to contactants, peripheral blood T- and B-cell percentages, in vitro lymphocyte responses to a mitogen, or the prevalence of autoantibodies. Generalized immunologic abnormalities in patients with lepromatous leprosy are neither predisposing causes nor necessary accompaniments of lepromatous leprosy, but are probably remote sequellae of the illness. By implication, the generalized immunologic abnormalities reported in other diseases are likely to be remote sequellae of the particular illness.

(Arch Dermatol 112:791-800, 1976)

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