To the Editor.—
It has been well established that patients who demonstrate aspirin intolerance can cross-react with a myriad of structurally unrelated and nontherapeutic substances.1 Often, these cross-sensitizers remain dangerously unrecognized even after a detailed history or after consulting a readily available reference such as the Physicians Desk Reference. Hydrazine yellow (tartrazine), a yellow coloring for foods and medicinal capsules is an increasingly common example of such a cross-sensitizer.2,3 We report a patient with "intrinsic asthma," including aspirin intolerance, who recently began therapy with ibuprofen (Motrin), an orange capsule containing tartrazine, in an attempt to alleviate pain associated with osteoarthritis.The patient is a 64-year-old woman who had been treated in the Dermatology Clinic at the University of Cincinnati Medical Center for atopic dermatitis. In addition, the patient's past history revealed adult-onset asthma, nasal polyps, and an intolerance to aspirin as manifested by acute urticaria. She returned recently
Olsen TG, Feldman M. Reaction with Ibuprofen in Aspirin Sensitivity Through Tartrazine Colorant. Arch Dermatol. 1976;112(6):883. doi:10.1001/archderm.1976.01630300079024
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