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The letter I wrote in August 1975 reported that such a phenomenon as lymphangitis developing as a result of the topical application of cantharidin on warts can indeed occur. If the same process has occurred after the use of other chemicals, it only means that other agents can do likewise. It is not known whether the lymphangitis after caustic cutaneous injuries is aseptic or transiently septic because of the difficulty in obtaining definitive cultures. I believe that every dermatologist should be aware of all possible complications of any therapeutic regimen he uses.