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July 1976

The Safety of Psoralens

Arch Dermatol. 1976;112(7):1036. doi:10.1001/archderm.1976.01630310082033

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To the Editor.—  Because of the interest in the last few years regarding the use of psoralens as a safe and effective means of repigmenting skin and acquiring a dark suntan, we believe the following case should be reported.

Report of a Case.—  In April 1975, a 37-year-old man was admitted to the University of California Hospital (San Francisco) for treatment of a severe phototoxic reaction. The patient had gone to Puerto Vallarta, Mexico, where he began taking 80 mg of trioxsalen (Trisoralen) daily, followed two hours later by a carefully measured one-hour exposure to the sun between four and five o'clock in the afternoon. It is noteworthy that he used aminobenzoic acid lotion (Pre Sun) on his entire body, so as to protect himself from ultraviolet-B radiation (wavelengths of 290 to 320 nm). Also, he used a red veterinary petroleum-aminobenzoic acid (RVP-PABA) stick on his lips for additional protection. For

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