To the Editor.—
We published cases of the dystrophic type of epidermolysis bullosa hereditaria congenita in uniovular male twins.1 In the treatment of these cases we administered vitamin E, 400 mg daily, intramuscularly first, in tablet form later. The treatment was given continually from Oct 14,1974 to Jan 5,1975, without beneficial effect on the lesions. During this treatment, no iron-containing medicaments were given to patients.In another patient with a dystrophic type of epidermolysis bullosa hereditaria congenita, a 15-year-old girl, we gave the same medicament, also without effect. Some effect was observed in all of our cases when we combined vitamin E therapy with low doses of corticosteroids (15 mg of prednisone daily).According to Rook2, "corticosteroids in high dosage may be life-saving and may prevent deformity in infancy and early childhood. The dose should be increased until bulla formation is controlled and then progressively reduced." In 1971,
Šalamon T. Treatment of Epidermolysis Bullosa Hereditaria Congenita. Arch Dermatol. 1976;112(7):1036. doi:10.1001/archderm.1976.01630310082035
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