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July 1976

Animal Models in Dermatology: Relevance to Human Dermatopharmacology and Dermatotoxicology

Author Affiliations

Oakland, Calif

Arch Dermatol. 1976;112(7):1046. doi:10.1001/archderm.1976.01630310088039

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This book is a collection of papers presented at a symposium at the University of California School of Medicine in San Francisco in September 1974. Reviewers of books such as this never tire of piously noting that edited books with several contributing authors are uneven. What seems more relevant to this volume is to comment on the markedly different interpretations that these authors have made of their assigned subjects. Thus, Mershon and Callahan have written a semiphilosophical essay containing the observation that "the dermatologic relevance of an animal model, like beauty, often lies in the eyes of the beholder." Marzulli and Maibach contributed a historical review of how the toxic potential of hexachlorophene was recognized and how this recognition might have occurred in less than the 20 years it required.

By contrast, some authors provide a step-by-step "how-to" description. For example, Mills and Kligman encourage weekend vacations in describing

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