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August 1976

Cross-Sensitivity of Common Aminoglycoside Antibiotics

Author Affiliations

From the Division of Toxicology, Bureau of Foods, Food and Drug Administration, US Department of Health, Education, and Welfare, Washington, DC.

Arch Dermatol. 1976;112(8):1101-1107. doi:10.1001/archderm.1976.01630320011002

• Guinea pigs were sensitized to neomycin (A, B, or C), paromomycin, gentamicin, kanamycin, streptomycin, and dihydrostreptomycin via intradermal or footpad injection with an adjuvant containing killed Mycobacterium butyricum or M tuberculosis H37Ra (Ra). These antibiotics produced greater cross-sensitization with an increase in the number of immunizations and chemical structural similarities. After repeated intradermal injections (adjuvant Ra) of neomycin, guinea pigs showed cross-sensitization to paromomycin, kanamycin, and streptomycin. A single intradermal injection of one of these antibiotics produced stronger reactions to the most closely related antibiotics, with no meaningful sensitization to the least-related allergens. Streptomycin-sensitized guinea pigs seldom showed a meaningful cross-sensitization to dihydrostreptomycin or the other antibiotics (except neomycin C); however, guinea pigs sensitized to dihydrostreptomycin or the other antibiotics often showed strong cross-sensitization to streptomycin.

(Arch Dermatol 112:1101-1107, 1976)

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