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August 1976

Dapsone-Induced Motor Polyneuropathy: A Complication of Prolonged Treatment of Subcorneal Pustular Dermatosis

Author Affiliations

From the Department of Neurology (Dr Fredericks), and the Section of Dermatology, Department of Medicine (Drs Kugelman and Kirsch), Hartford Hospital, Conn.

Arch Dermatol. 1976;112(8):1158-1160. doi:10.1001/archderm.1976.01630320064020

• A motor polyneuropathy developed in a woman with subcorneal pustular dermatosis of 16 years' duration, who had received at least 300 gm of dapsone over a five-year period and 80 gm during the four-month period of progression of her neurologic symptoms. Although the patient believed her muscle power had returned to normal four months after the drug was stopped, a slight peripheral neuropathy remained. Electrodiagnostic and clinical features during the period of greatest weakness and the subsequent 16 months were consistent with a polyneuropathy of the axonal type. The neurotoxicity of dapsone appears to be dosedependent, but the mechanism by which it occurs is unknown.

(Arch Dermatol 112:1158-1160, 1976)

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