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September 1976

Lichen Planus Pemphigoides: Immunofluorescence Findings

Author Affiliations

From the Department of Dermatology, Mount Sinai School of Medicine of the City University of New York.

Arch Dermatol. 1976;112(9):1280-1283. doi:10.1001/archderm.1976.01630330042011

• A 56-year-old woman developed a vesicular and bullous eruption followed by an efflorescence of lichenoid papules. The clinical and histologic features of this case were consistent with a diagnosis of lichen planus pemphigoides. Direct and indirect immunofluorescence studies demonstrated both in vivo-bound and circulating IgG with specificity for the epidermal basement membrane zone. A common pathogenic immunologic mechanism may exist for both lichen planus and lichen planus pemphigoides, which we believe are clinical variants of a similar disease process.

(Arch Dermatol 112:1280-1283, 1976)

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